What is amyotrophic lateral sclerosis (ALS)?

ALS is a rare, progressive, and fatal disease that usually affects people between the ages of 40 and 70. For people with ALS, nerve cells in the brain and spinal cord that normally help control muscle function become impaired. These nerves—known as motor neurons—degenerate and eventually die, leading to loss of muscle function throughout the body.

Understanding ALS

ALS can affect people differently. Its early signs and symptoms often include weakness in the limbs, muscle cramping and twitching, labored speech and breathing, and difficulty swallowing. These symptoms spread and worsen as ALS progresses, eventually resulting in paralysis and respiratory failure.

Experts believe that ALS may be caused by a combination of genetics and environmental or lifestyle factors. In recent years, researchers have expanded their understanding of the link between genetics and ALS.

Although the number of people living with ALS may seem small, the impact of the disease is not. ALS not only impacts those living with it, but also their families, caregivers, and even future generations.

How ALS is diagnosed

The process of diagnosing ALS can be a lengthy one. Find out more about the steps your doctor may take to reach a diagnosis.

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In the background genetic sequences and in front a man smiling
Neurofilaments: important biomarkers for ALS

Neurofilaments are structural proteins that help make up our neurons. Learn how neurofilament levels can help us detect
and monitor ALS.

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In the background genetic sequences and in front a man smiling
Familial and sporadic ALS

Not all ALS is the same. Learn what differentiates familial
ALS (fALS) from sporadic ALS (sALS).

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Abstract image of genetic sequencing
What is genetic ALS?

The link between genetic mutations and familial ALS (fALS) has been established, but even seemingly sporadic ALS (sALS) could have a genetic component.

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Genetic profile being analyzed by HCP – ready to circle the anomalies with a pencil
Genetic ALS fast facts

Here are some fast facts to help you gain a better understanding of ALS and to prepare you for when you discuss ALS with your doctor.

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